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KMID : 0355419990230010063
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Journal of Korean Academy of Oral Health
1999 Volume.23 No. 1 p.63 ~ p.73
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Effect of growth inhibitory substances isolated from Acinetobacter sp. on the growth of some oral bacteria
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1/2조철호/12Cheol Ho Cho
1/2민윤기/1/2장기완/12Youn Ki Min/12Kee Wan Chang
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Abstract
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-Abstract-
The production of growth inhibitory subtances in the bacterial world is ubiquitous.
Growth inhibitory substances inhibit the growth of other starains of bacteria. They are
proteins which are often complexed with lipids and/or carbohydrates.
The purpose of this study is to investigate in vitro antibacterial effect of Acinetobacter
sp. on some oral bacteria. A growth inhibitory substances from Acinetobacter agents.
We purified partially and examined the effect of growth inhibitory substances on the
growth of some oral bacteria. Assays for inhibitory activity were studied by a diffusion
method. The inhibitory activity was determined on the basis of the diameter of zones of
growth inhibition.
It had potent antibacterial effects, in vitro, against Capnocytophaga and Streptococcus
species.
The results obtained were as follows.
1. The microbial isolate with growth inhibitory activity from soil was classified into
Acinetobacter sp..
2. Acinetobacter sp. was resistant to its growth inhibitory substance but C. ochracea
ATCC 27872, C. sputigena ATCC 33612, C. gingivalis ATCC 33624, S. mutans KCTC
3065, S. sobrinus KCTC 3308, and S. cricetus KCTC 3292 strians were sensitive to it.
3. Growth inhibitory substance of Acinetobacter sp. was secreted into culture media.
This substance was stable at 40℃ for 3 hours, but completely inactivated at 55℃ for 30
minute. It was sensitive to trypsin and proteinase K, which suggest proteinous
substance.
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